Trenbolone (Trenbolone Acetate)
The drug Trenbolone is, without a doubt, the most powerful injectable anabolic steroid used by HGH-dude.com members to gain muscle. However the full properties of the drug are not always fully understood. This profile will separate fact from fiction and help steroid.com members decide if Trenbolone is right for them.
Trenbolone is similar to the highly popular steroid Nandrolone, in that they are both 19-nor steroids, meaning that a testosterone molecule has been altered at the 19th position to give us a new compound. Unlike Nandrolone however Trenbolone is an excellent mass and hardening drug with the majority of gains being muscle fiber, with minimal water retention (1) It has an unbelievable anabolic (muscle building) score of 500. When you compare that to Testosterone, which itself is a powerful mass builder, and has an anabolic score of 100 you can begin to fathom the muscle building potential of Trenbolone. What makes Trenbolone so anabolic? Numerous factors come into play. Trenbolone greatly increases the level of the extremely anabolic hormone IGF-1 within muscle tissue (2). And, its worth noting that not only does it increase the levels of IGF-1 in muscle over two fold, it also causes muscle satellite cells (cells that repair damaged muscle) to be more sensitive to IGF-1 and other growth factors(3). The amount of DNA per muscle cell may also be significantly increased (3).
Trenbolone also has a very strong binding affinity to the androgen receptor (A.R), binding much more strongly than testosterone (4). This is important, because the stronger a steroid binds to the androgen receptor the better that steroid works at activating A.R dependent mechanisms of muscle growth. There is also strong supporting evidence that compounds which bind very tightly to the androgen receptor also aid in fat loss. Think as the receptors as locks and androgen's as different keys, with some keys (androgen's) opening (binding) the locks (receptors) much better than others. This is not to say that AR-binding is the final word on a steroids effectiveness. Anadrol doesnt have any measurable binding to the AR& and we all know how potent Anadrol is for mass-building.
Trenbolone increases nitrogen retention in muscle tissue (5). This is of note because nitrogen retention is a strong indicator of how anabolic a substance is. However, it's incredible mass building effects do not end there. Trenbolone has the ability to bind with the receptors of the anti-anabolic (muscle destroying) glucocorticoid hormones (6). This may also has the effect of inhibiting the catabolic (muscle destroying) hormone cortisol (7).
Yet another amazing trait that must be noted is its ability to improve feed efficiency and mineral absorption in animals given the drug (8). To help you understand what this means for you, feed efficiency is a measurement of how much of an animals diet is converted into meat, and the more food it takes to produce this meat, the lower the efficiency. Conversely, the less food it takes to produce meat the, higher the efficiency& well you get the idea. Animals given Trenbolone gained high quality weight without having their diet adjusted, thus improving feed efficiency. Finding new compounds which can improve feed efficiency is a billion dollar industry, and has spawned many nutritional advances in the bodybuilding world over the last few decades (CLA, Whey Protein, and HMB are compounds which spring to mind as having first been introduced by the livestock industry). What does this translate to for the hard training athlete? The food you eat will be better utilized for building lean muscle, and vitamins and minerals are also better absorbed which may keep you healthier during cycle.
Trenbolone is also a highly androgenic hormone, when compared with Testosterone, which has an androgenic ratio of 100; Trenbolone's androgenic ratio is an astonishing 500. Highly androgenic steroids are appreciated for the effects they have on strength as well as changing the estrogen/androgen ratio, thus reducing water and under the skin. As if the report on Trenbolone was not good enough, it gets better; Trenbolone is extraordinarily good as a fat loss agent. One reason for this is its powerful effect on nutrient partitioning (9). It is a little known fact is that androgen receptors are found in fat cells as well as muscle cells(10), androgens act directly on the A.R in fat cells to affect fat burning.(11) the stronger the androgen binds to the A.R, the higher the lipolytic (fat burning) effect on adipose tissue (fat)(11). Since some steroids even increase the numbers of A.R in muscle and fat (11, 12) this fat loss effect would be amplified with the concurrent use of other compounds, such as Testosterone.
Trenbolone promotes red blood cell production and increases the rate of glycogen replenishment, significantly improving recovery (13). Like almost all steroids, it's effects are dose dependant with higher dosages having the greatest effects on body composition and strength. Mental changes are a notorious side effect of Trenbolone use (15), androgens increase chemicals in the brain that promote aggressive behavior(16), which can be beneficial for some athletes wanting to improve speed and power.
Trenbolone's chemical structure makes it resistant to the aromatize enzyme (conversion to estrogen) thus absolutely no percentage of Trenbolone will convert to estrogen. Trenbolone administration would not promote estrogenic side effects such as breast tissue growth in men (gynecomastia, bitch tits) accelerated fat gain, decline in fat break down and water retention. Trenbolone is also resistant to the 5- alpha-reductase enzyme, this enzyme reduces some steroid hormones into a more androgenic form, in this case however this does not matter. Trenbolone boasts an androgenic ratio of 500. It can easily cause adverse androgenic side effects in people who are prone to hair loss, prostate enlargement, oily skin and acne. Unfortunately Trenbolone's potential negative side effects do not end there. Trenbolone is also a noted progestin: it binds to the receptor of the female sex hormone progesterone (with about 60% of the actual strength progesterone) (17). In sensitive people this can lead to bloat and breast growth worse still, Trenbolone's active metabolite 17beta-trenbolone has a binding affinity to the progesterone receptor (PgR) that is actually greater than progesterone itself (18). No need to panic though, the anti-estrogens letrzole or fulvestrant can lower progesterone levels, and combat any progestenic sides. The use of a 19-nor compound like trenbolone also increases prolactin & . bromocriptine or cabergoline are often recommended to lower prolatin levels (20). Testicular atrophy (shrunken balls) may also occur; HCG used intermittently throughout a cycle can prevent this. (21) It is also wise for Tren users to closely monitor their cholesterol levels, as well as kidney function and liver enzymes, as Tren has the potential to negatively affect all of those functions. Finaplix, being a powerful progestin, will also shut down natural testosterone production which even a relatively small dose and keep the testosterone level suppressed for an extended period of time, this can lower libido and cause erectile dysfunction (fina dick). It is essential that you always stack Finaplix with testosterone.
The acetate ester is a very short-chain ester attached to the Finaplix molecule. It has an active life of 2-3 days but to keep blood levels of trenbolone elevated and steady, daily injections are often recommended. The acetate ester provides a rapid and high concentration of the hormone which is beneficial to those seeking quick gains, coupled with a rapid clearing time the acetate ester can be discontinued on the onset of adverse side effects.
Now that the properties of Trenbolone Acetate have been explained we can better understand how to use it in order to maximize its advantages. Evidence suggests that Finaplix when stacked with estrogen promotes more weight gain that Trenbolone alone(22), now Im not telling you to go pop some birth control with your Tren but the addition of aromatizing orals such as Dianabol and a long estered testosterone such as Cypionate or Enanthate would produce great gains in a bulking cycle. For a cutting cycle Finaplix is the best choice you have; Trenbolone's powerful effect on nutrient shuttling allows a user to restrict calories and remain in a state of positive nitrogen balance (remember what that means?). The cortisol reducing effect and binding to the glucocorticoid receptor will greatly reduce the catabolic effects of harsh dieting and excessive amounts of cardio and not to mention that Finaplix itself may burn fat (due to its strong AR-binding). A good choice to stack with Tren in a cutting cycle is Winstrol. Winstrol has a low binding affinity to the AR and thus will act in your body in vastly different ways than the Tren (i.e. in non-receptor mediated action). In addition, Winstrol is a DHT-based drug and Tren is a 19-nor& throw in some Testosterone (prop), and you'll have a cutting cycle which takes advantage of all 3 major families of Anabolic Steroids (Testosterone, 19-nor, and DHT), as well as vastly different AR-binding affinities and mechanisms of action.
Ironically, even though Trenbolone ( Tren ) is an excellent contest prep drug, it lowers your thyroid level(23), and this raises prolactin. I recommend taking T3 (25mcgs/day) along with your Tren to avoid elevating your prolactin too high via this route.
Also, this drug is a poor choice for athletes who rely on cardiovascular fitness to play a sport. Trenbolone ( Tren ), anecdotally at least, reduces many athletes ability to sustain high levels of endurance. Unfortunately, this makes Tren a poor choice for many.
As of now the main source of Trenbolone is from implants for cattle being converted into an injectable or transdermal compound, from powder, and of course Underground Labs. "Home brewing" powder or cattle implants seems to be the preferred method of obtaining injectable Trenbolone Acetate, because the user would have much more control over the potency and sterility of the drug. Trenbolone is much more expensive than other anabolic steroids ranging from 15 U.S dollars per gram of powder or 150 U.S for a single 10 ml bottle. The cost of Trenbolone should not matter, it is worth every penny.
Trenbolone Acetate Profile
(Trenbolone Base + Acetate Ester)
Formula: C20 H24 O3
Molecular Weight: 312.4078
Molecular Weight (base): 270.3706
Molecular Weight (ester):60.0524
Formula (base): C18 H22 O2
Formula (ester): C2 H4 O2
Melting Point (base): 183-186C
Melting Point (ester):16.6C
Manufacturer: Cattle implants, British Dragon, Various
Effective Dose (Men):50-150mg ED
Effective Dose (Women): Not recommended
Active life: 2-3 days
Detection Time: 5 months
Anabolic/Androgenic ratio: 500/500
A good Trenbolone cycle can be one of the best cycles any performance enhancer will ever complete and while there are many forms and plans to choose from disappointment is rarely a concern you will have. As it is the easiest to control and the most widely available Trenbolone Acetate will be our preferred and recommended Tren form; it is not a must, you can use Trenbolone-Enanthate or Trenbolone- Hexahydrobencylcarbonate (Parabolan) if you so choose but the Acetate form is generally the most efficient. As you may already understand a Trenbolone cycle can be during a period of growth or dieting and in most cases it is equally effective in both; in-fact, it is such an amazing steroid many performance enhancers choose to include it in most of their cycles regardless of purpose.
The Basic Trenbolone Cycle:
While it may be a basic Trenbolone cycle that by no means implies that it is weak but this will be a good place for a first time Tren user to start and in many cases it will be as extensive as many will ever need to go. Your basic Trenbolone cycle will always include testosterone; in-fact we must recommend testosterone with all Trenbolone cycles as the Tren hormone is very suppressive to natural testosterone production; so much so that without testosterone therapy you would have no testosterone in play.
For this Trenbolone cycle our dosing will be at 50mg every other day; if you tolerate that dosing well and still want more 75mg every other day can be well justified. In most cases, regardless of the specific dose the total duration of use will be for 8 weeks; 12 weeks can be used but 8 is far more tolerable by most and in the name of health generally a good place to end. If you are going to enter the 12 week mark of use it is generally better to have some experience with the hormone and to be practicing such methods for very specific purposes such as a competition. For the off-season Trenbolone cycle you will find it stacks very well with testosterone and Dianabol as well as Anadrol if you so choose. During your cutting phase Tren will stack well again with testosterone and other anabolics such as Winstrol and Anavar.
Advanced Trenbolone Cycle:
An advanced Trenbolone cycle will always begin at 100mg every other day and often and in many cases creep its way into dosing levels of 100mg every single day during use. Such every day doses are generally not needed for the off-season athlete; such doses are not going to create enough added growth to warrant the added physical stress; however, daily doses of 100mg per day can be very useful during a diet, particularly later on in the diet close to a competition.
For the off-season advanced Trenbolone cycle of 100mg every other day many will find a combo of Test/Tren/Dbol to be just about unbeatable but for the truly advanced users we at many times recommend an overlapping method. For an effective overlapping Trenbolone cycle the individual might supplement with testosterone and Deca-Durabolin for 12 weeks but at the 10 week mark he would have added in Tren to the equation and by week 12 discontinued his Deca and stuck with Tren and Testosterone only. An overlapping Trenbolone cycle might look like this (example does not include orals such as Dianabol or Anadrol):
Week 1-20 Testosterone
Week 1-12 Deca-Durabolin
Week 10-20 Trenbolone
For the dieting or cutting Trenbolone cycle this is where things can get really exciting as the choices are truly endless. In most cases you will be best served by supplementing with your Tren the latter half of the dieting phase; for example, if you are going to diet for 16 weeks you will want to use the Tren the last 8-12 weeks rather than from the start. You can also use the same overlapping method here as well; many athletes enjoy a Trenbolone cycle that overlaps with Equipoise during this period of use. As for other items, Winstrol, as always testosterone, good AIs and fat burners and if you can swing it a good batch of HGH and youll have a cycle that's hard to beat.